Activin T. Of monocyte-derived dendritic cells 559560 but inhibited the ability of dendritic cells to mature and stimulate T cell activation. Various cells synthesize activin and have a specific binding site for this peptide.
In vitro activin A secretion was increased following irradiation of mouse and human breast cancer cells and its expression was further enhanced upon TGFβ blockade. Activin A promotes regulatory T cell-mediated immunosuppression in irradiated breast cancer. Activin a member of the transforming growth factor beta protein family was originally isolated from gonadal fluids and stimulates the release of pituitary follicle-stimulating hormone FSH.
Activin has numerous functions in both normal and neoplastic cells.
Activins primarily signal through SMAD23 proteins to regulate a variety of functions including cell proliferation differentiation wound healing apoptosis and metabolism McDowell et al 1997. 561562 Inhibitory effects of activin A on the antigen-presenting activity of macrophages have been observed as well 563 and activin A. Academic Article Overview abstract. Although TGF-β signaling is a critical step in the differentiation of naïve CD4 T cells into CD4 Foxp3 T reg cells activin-A can also induce Foxp3 expression and promote the generation of T reg cells 26 27.